Symbol
Name
ID

Stat5b
signal transducer and activator of transcription 5B
MGI:103035

Phenotype annotations related to endocrine/exocrine glands

Darker colors indicate more annotations

Human Phenotypes	Decreased serum insulin-like growth factor 1	Decreased response to growth hormone stimulation test	Thyroiditis	Delayed puberty
Disease(s) Associated with STAT5B	Decreased serum insulin-like growth factor 1	Decreased response to growth hormone stimulation test	Thyroiditis	Delayed puberty
growth hormone insensitivity syndrome with immune dysregulation 1
growth hormone insensitivity syndrome with immune dysregulation 2

Mouse Phenotypes

abnormal milk ejection

disorganized pancreatic islets

decreased thymocyte number

abnormal mammary gland development

abnormal branching of the mammary ductal tree

abnormal mammary gland growth during lactation

abnormal mammary gland alveolus morphology

decreased insulin secretion

abnormal mammary gland physiology

hypolactation

lactation failure

increased mammary gland apoptosis

Availability

Mouse Genotype

Stat5b^tm1Hwd/Stat5b^tm1Hwd

Stat5b^tm1Jni/Stat5b^tm1Jni

Stat5b^tm1Mam/Stat5b^tm1Mam
Tg(MMTV-cre)4Mam/0 (conditional)

Stat5b^tm1Mam/Stat5b^tm1Mam
Tg(Wap-cre)11738Mam/0 (conditional)

Stat5b^tm1Mam/Stat5b^tm1Mam
Tg(Ins2-cre)25Mgn/0 (conditional)

Stat5b^tm1Mam/Stat5b^tm1Mam
Tg(Pdx1-cre)89.1Dam/0 (conditional)

Stat5b^tm1Mam/Stat5b^tm1Mam
Tg(MMTV-cre)1Mam/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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